Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts

Scleroderma is an autoimmune disease that causes dermal fibrosis. It occurs when collagen accumulates in tissue as a result of persistent inflammation. Th17 cells and pro-inflammatory cytokines such as IL-1β, IL-6, IL-17, and TNF-α play important roles in the pathogenesis of scleroderma. Because met...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Moon, Jeonghyeon, Lee, Seon-yeong, Choi, Jeong Won, Lee, A Ram, Yoo, Jin Hee, Moon, Su-Jin, Park, Sung-Hwan, Cho, Mi-La
Format: Artigo
Language:Inglês
Published: BioMed Central 2021
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097822/
https://ncbi.nlm.nih.gov/pubmed/33947424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-021-02860-z
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