Metformin Suppresses Systemic Autoimmunity in Roquin(san/san) Mice through Inhibiting B Cell Differentiation into Plasma Cells via Regulation of AMPK/mTOR/STAT3

Circulating autoantibodies and immune complex deposition are pathological hallmarks of systemic lupus erythematosus (SLE). B cell differentiation into plasma cells (PCs) and some T cell subsets that function as B cell helpers can be therapeutic targets of SLE. Mechanistic target of rapamycin (mTOR)...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Lee, Seon-Yeong, Moon, Su-Jin, Kim, Eun-Kyung, Seo, Hyeon-Beom, Yang, Eun-Ji, Son, Hye-Jin, Kim, Jae-Kyung, Min, Jun-Ki, Park, Sung-Hwan, Cho, Mi-La
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2017
Assuntos:
Immune Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357783/
https://ncbi.nlm.nih.gov/pubmed/28242651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1403088
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