Erosion of human X chromosome inactivation causes major remodeling of the iPSC proteome

X chromosome inactivation (XCI) is a dosage compensation mechanism in female mammals whereby transcription from one X chromosome is repressed. Analysis of human induced pluripotent stem cells (iPSCs) derived from female donors identified that low levels of XIST RNA correlated strongly with erosion o...

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Publicado no:Cell Rep
Main Authors: Brenes, Alejandro J., Yoshikawa, Harunori, Bensaddek, Dalila, Mirauta, Bogdan, Seaton, Daniel, Hukelmann, Jens L., Jiang, Hao, Stegle, Oliver, Lamond, Angus I.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097692/
https://ncbi.nlm.nih.gov/pubmed/33910018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109032
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