Population Pharmacokinetic and Pharmacodynamic Target Attainment Analysis of Cefazolin in the Serum and Hip Joint Capsule of Patients Undergoing Total Hip Arthroplasty

The objectives of this study were to evaluate the population pharmacokinetics of prophylactic cefazolin (CFZ) from its serum and hip joint capsule concentrations in patients undergoing total hip arthroplasty and to establish the pharmacodynamic target concentration exceeding the MIC for designing an...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Komatsu, Toshiaki, Natsume, Yui, Uchiyama, Katsufumi, Ikeda, Shinsuke, Tomoda, Yoshinori, Takayama, Yoko, Takaso, Masashi, Hanaki, Hideaki, Atsuda, Koichiro
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2021
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097485/
https://ncbi.nlm.nih.gov/pubmed/33526489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02114-20
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