Optimizing Aminoglycoside Dosing Regimens for Critically Ill Pediatric Patients with Augmented Renal Clearance: a Convergence of Parametric and Nonparametric Population Approaches

Augmented renal clearance (ARC) can occur in critically ill pediatric patients receiving aminoglycosides such as gentamicin and tobramycin, yet optimal dosing strategies for ARC are undefined. We evaluated the probability of achieving efficacious or toxic exposures in pediatrics. Parallel population...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Avedissian, Sean N., Rohani, Roxane, Bradley, John, Le, Jennifer, Rhodes, Nathaniel J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2021
Assuntos:
Clinical Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097479/
https://ncbi.nlm.nih.gov/pubmed/33526481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02629-20
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