Optimizing Aminoglycoside Dosing Regimens for Critically Ill Pediatric Patients with Augmented Renal Clearance: a Convergence of Parametric and Nonparametric Population Approaches

Augmented renal clearance (ARC) can occur in critically ill pediatric patients receiving aminoglycosides such as gentamicin and tobramycin, yet optimal dosing strategies for ARC are undefined. We evaluated the probability of achieving efficacious or toxic exposures in pediatrics. Parallel population...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Avedissian, Sean N., Rohani, Roxane, Bradley, John, Le, Jennifer, Rhodes, Nathaniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097479/
https://ncbi.nlm.nih.gov/pubmed/33526481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02629-20
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