Population Pharmacokinetics of Imipenem in Critically Ill Patients: A Parametric and Nonparametric Model Converge on CKD-EPI Estimated Glomerular Filtration Rate as an Impactful Covariate

BACKGROUND: Population pharmacokinetic (popPK) models for antibiotics are used to improve dosing strategies and individualize dosing by therapeutic drug monitoring. Little is known about the differences in results of parametric versus nonparametric popPK models and their potential consequences in cl...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: de Velde, Femke, de Winter, Brenda C. M., Neely, Michael N., Yamada, Walter M., Koch, Birgit C. P., Harbarth, Stephan, von Dach, Elodie, van Gelder, Teun, Huttner, Angela, Mouton, Johan W.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329758/
https://ncbi.nlm.nih.gov/pubmed/31956969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-020-00859-1
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