Population Pharmacokinetics of Imipenem in Critically Ill Patients: A Parametric and Nonparametric Model Converge on CKD-EPI Estimated Glomerular Filtration Rate as an Impactful Covariate

BACKGROUND: Population pharmacokinetic (popPK) models for antibiotics are used to improve dosing strategies and individualize dosing by therapeutic drug monitoring. Little is known about the differences in results of parametric versus nonparametric popPK models and their potential consequences in cl...

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Pubblicato in:Clin Pharmacokinet
Autori principali: de Velde, Femke, de Winter, Brenda C. M., Neely, Michael N., Yamada, Walter M., Koch, Birgit C. P., Harbarth, Stephan, von Dach, Elodie, van Gelder, Teun, Huttner, Angela, Mouton, Johan W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2020
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Original Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7329758/
https://ncbi.nlm.nih.gov/pubmed/31956969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-020-00859-1
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