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Artemisinin-Based Drugs Target the Plasmodium falciparum Heme Detoxification Pathway
Artemisinin (ART)-based antimalarial drugs are believed to exert lethal effects on malarial parasites by alkylating a variety of intracellular molecular targets. Recent work with live parasites has shown that one of the alkylated targets is free heme within the parasite digestive vacuole, which is l...
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| Veröffentlicht in: | Antimicrob Agents Chemother |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8097475/ https://ncbi.nlm.nih.gov/pubmed/33495226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02137-20 |
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