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Artemisinin-Based Drugs Target the Plasmodium falciparum Heme Detoxification Pathway

Artemisinin (ART)-based antimalarial drugs are believed to exert lethal effects on malarial parasites by alkylating a variety of intracellular molecular targets. Recent work with live parasites has shown that one of the alkylated targets is free heme within the parasite digestive vacuole, which is l...

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Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Ribbiso, Kaleab A., Heller, Laura E., Taye, Abigail, Julian, Erin, Willems, Andreas V., Roepe, Paul D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097475/
https://ncbi.nlm.nih.gov/pubmed/33495226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02137-20
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