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Inhibiting Plasmodium falciparum growth and heme detoxification pathway using heme-binding DNA aptamers
The human parasite Plasmodium falciparum enzymatically digests hemoglobin during its intra-erythrocytic developmental stages in acidic food vacuole compartments. The released heme is rapidly detoxified by polymerization into the chemically inert pigment, hemozoin. Several heme-binding anti-malarial...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2726426/ https://ncbi.nlm.nih.gov/pubmed/19633187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906370106 |
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