Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance

Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial drug development utilizes preclinical murine and experimental human malaria infection studies to evaluate drug efficacy. A sequential approach is typically adapted, with results from each stage inform...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Burgert, Lydia, Zaloumis, Sophie, Dini, Saber, Marquart, Louise, Cao, Pengxing, Cherkaoui, Mohammed, Gobeau, Nathalie, McCarthy, James, Simpson, Julie A., Möhrle, Jörg J., Penny, Melissa A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2021
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097426/
https://ncbi.nlm.nih.gov/pubmed/33526486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01539-20
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