Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance

Antzeko izenburuak

• Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development
  nork: Burgert, Lydia, et al.
  Argitaratua: (2020)
• Defining the Effectiveness of Antimalarial Chemotherapy: Investigation of the Lag in Parasite Clearance Following Drug Administration
  nork: Khoury, David S., et al.
  Argitaratua: (2016)
• Retrospective Analysis Using Pharmacokinetic/Pharmacodynamic Modeling and Simulation Offers Improvements in Efficiency of the Design of Volunteer Infection Studies for Antimalarial Drug Development
  nork: Andrews, Kayla Ann, et al.
  Argitaratua: (2020)
• A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048
  nork: McCarthy, James S, et al.
  Argitaratua: (2020)
• Pharmacokinetic/pharmacodynamic modelling of the antimalarial effect of Actelion‐451840 in an induced blood stage malaria study in healthy subjects
  nork: Krause, Andreas, et al.
  Argitaratua: (2016)