Comparative Pharmacodynamics of Echinocandins against Aspergillus fumigatus Using an In Vitro Pharmacokinetic/Pharmacodynamic Model That Correlates with Clinical Response to Caspofungin Therapy: Is There a Place for Dose Optimization?

Echinocandins have been used as primary therapy of invasive aspergillosis (IA), with suboptimal results at standard dosing. Here, we explored the efficacy of dose escalation in a validated in vitro pharmacokinetic/pharmacodynamic (PK/PD) model. Six echinocandin wild-type (WT) and three non-WT A. fum...

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Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Siopi, Maria, Perlin, David S., Arendrup, Maiken C., Pournaras, Spyros, Meletiadis, Joseph
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2021
Предметы:
Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097425/
https://ncbi.nlm.nih.gov/pubmed/33495222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01618-20
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