SIRT7 modulates the stability and activity of the renal K‐Cl cotransporter KCC4 through deacetylation

SIRT7 is a NAD(+)‐dependent deacetylase that controls important aspects of metabolism, cancer, and bone formation. However, the molecular targets and functions of SIRT7 in the kidney are currently unknown. In silico analysis of kidney transcripts of the BXD murine genetic reference population reveal...

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Publicado no:EMBO Rep
Main Authors: Noriega, Lilia G, Melo, Zesergio, Rajaram, Renuga D, Mercado, Adriana, Tovar, Armando R, Velazquez‐Villegas, Laura A, Castañeda‐Bueno, María, Reyes‐López, Yazmín, Ryu, Dongryeol, Rojas‐Vega, Lorena, Magaña‐Avila, German, López‐Barradas, Adriana M, Sánchez‐Hernández, Mariana, Debonneville, Anne, Doucet, Alain, Cheval, Lydie, Torres, Nimbe, Auwerx, Johan, Staub, Olivier, Gamba, Gerardo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097349/
https://ncbi.nlm.nih.gov/pubmed/33749979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050766
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