N-terminal Serine Dephosphorylation Is Required for KCC3 Cotransporter Full Activation by Cell Swelling

The K(+):Cl(−) cotransporter (KCC) activity is modulated by phosphorylation/dephosphorylation processes. In isotonic conditions, KCCs are inactive and phosphorylated, whereas hypotonicity promotes their dephosphorylation and activation. Two phosphorylation sites (Thr-991 and Thr-1048) in KCC3 have b...

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Autors principals: Melo, Zesergio, de los Heros, Paola, Cruz-Rangel, Silvia, Vázquez, Norma, Bobadilla, Norma A., Pasantes-Morales, Herminia, Alessi, Dario R., Mercado, Adriana, Gamba, Gerardo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Membrane Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814743/
https://ncbi.nlm.nih.gov/pubmed/24043619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.475574
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