Activin/Nodal/TGF-β Pathway Inhibitor Accelerates BMP4-Induced Cochlear Gap Junction Formation During in vitro Differentiation of Embryonic Stem Cells

Mutations in gap junction beta-2 (GJB2), the gene that encodes connexin 26 (CX26), are the most frequent cause of hereditary deafness worldwide. We recently developed an in vitro model of GJB2-related deafness (induced CX26 gap junction-forming cells; iCX26GJCs) from mouse induced pluripotent stem c...

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Dades bibliogràfiques
Publicat a:Front Cell Dev Biol
Autors principals: Fukunaga, Ichiro, Oe, Yoko, Chen, Cheng, Danzaki, Keiko, Ohta, Sayaka, Koike, Akito, Ikeda, Katsuhisa, Kamiya, Kazusaku
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097046/
https://ncbi.nlm.nih.gov/pubmed/33968919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.602197
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