N6-methyladenosine demethylase FTO impairs hepatic ischemia–reperfusion injury via inhibiting Drp1-mediated mitochondrial fragmentation

Despite N6-methyladenosine (m6A) is functionally important in various biological processes, its role and the underlying regulatory mechanism in the liver remain largely unexplored. In the present study, we showed that fat mass and obesity-associated protein (FTO, an m6A demethylase) was involved in...

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Pubblicato in:Cell Death Dis
Autori principali: Du, Ying Dong, Guo, Wen Yuan, Han, Cong Hui, Wang, Ying, Chen, Xiao Song, Li, Da Wei, Liu, Jin Long, Zhang, Ming, Zhu, Nan, Wang, Xin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096847/
https://ncbi.nlm.nih.gov/pubmed/33947842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03622-x
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