N6-methyladenosine demethylase FTO impairs hepatic ischemia–reperfusion injury via inhibiting Drp1-mediated mitochondrial fragmentation

Despite N6-methyladenosine (m6A) is functionally important in various biological processes, its role and the underlying regulatory mechanism in the liver remain largely unexplored. In the present study, we showed that fat mass and obesity-associated protein (FTO, an m6A demethylase) was involved in...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Du, Ying Dong, Guo, Wen Yuan, Han, Cong Hui, Wang, Ying, Chen, Xiao Song, Li, Da Wei, Liu, Jin Long, Zhang, Ming, Zhu, Nan, Wang, Xin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096847/
https://ncbi.nlm.nih.gov/pubmed/33947842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03622-x
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