Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3

To date, information on the ontogeny of renal transporters is limited. Here, we propose to estimate the in vivo functional ontogeny of transporters using a combined population pharmacokinetic (popPK) and physiology-based pharmacokinetic (PBPK) modeling approach called popPBPK. Clavulanic acid and am...

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Bibliographic Details
Published in:AAPS J
Main Authors: Cristea, Sînziana, Krekels, Elke H. J., Allegaert, Karel, De Paepe, Peter, de Jaeger, Annick, De Cock, Pieter, Knibbe, Catherijne A. J.
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096729/
https://ncbi.nlm.nih.gov/pubmed/33948771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-021-00595-9
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