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An amide mimic of desTHPdactylolide: Total synthesis and antiproliferative evaluation
(−)-Zampanolide is a unique microtubule stabilizing agent (MSA) with covalent-binding mechanism and low nanomolar anitproliferative potency towards multi-drug resistant cancer cells. MSAs have a special connection with prostate cancer by inhibiting androgen receptor nuclear translocation. Zampanolid...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8096693/ https://ncbi.nlm.nih.gov/pubmed/33753258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2021.127970 |
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