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Synthesis and antiproliferative evaluation of new zampanolide mimics

(–)–Zampanolide is a marine microtubule-stabilizing macrolide that has been shown by in vitro experiments to be a promising anticancer lead compound. Through its unique covalent-binding with β-tubulin, zampanolide exhibits cytotoxic potency towards multi-drug resistant cancer cells that is superior...

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Detalles Bibliográficos
Publicado en:Org Biomol Chem
Main Authors: Chen, Guanglin, Patanapongpibul, Manee, Jiang, Ziran, Zhang, Qiang, Zheng, Shilong, Wang, Guangdi, White, James D., Chen, Qiao-Hong
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555766/
https://ncbi.nlm.nih.gov/pubmed/30924817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9ob00556k
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