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Lipopolysaccharide-induced exosomal miR-146a is involved in altered expression of Alzheimer’s risk genes via suppression of TLR4 signaling
Repeated exposure to toll-like receptor 4 (TLR4) ligands, such as lipopolysaccharide (LPS), reduces responses of monocytes/macrophages to LPS (LPS/endotoxin tolerance). Microglial exposure to Aβ deposits, a TLR4 ligand, may cause “Aβ/LPS tolerance”, leading to decreased Aβ clearance. We demonstrated...
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| Published in: | J Mol Neurosci |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8096651/ https://ncbi.nlm.nih.gov/pubmed/33185814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-020-01750-1 |
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