Novel dopamine receptor 3 antagonists inhibit the growth of primary and temozolomide resistant glioblastoma cells

Treatment for the lethal primary adult brain tumor glioblastoma (GBM) includes the chemotherapy temozolomide (TMZ), but TMZ resistance is common and correlates with promoter methylation of the DNA repair enzyme O-6-methylguanine-DNA methyltransferase (MGMT). To improve treatment of GBMs, including t...

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發表在:PLoS One
Main Authors: Williford, Sarah E., Libby, Catherine J., Ayokanmbi, Adetokunbo, Otamias, Arphaxad, Gordillo, Juan J., Gordon, Emily R., Cooper, Sara J., Redmann, Matthew, Li, Yanjie, Griguer, Corinne, Zhang, Jianhua, Napierala, Marek, Ananthan, Subramaniam, Hjelmeland, Anita B.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2021
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096095/
https://ncbi.nlm.nih.gov/pubmed/33945569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0250649
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