Novel dopamine receptor 3 antagonists inhibit the growth of primary and temozolomide resistant glioblastoma cells

Treatment for the lethal primary adult brain tumor glioblastoma (GBM) includes the chemotherapy temozolomide (TMZ), but TMZ resistance is common and correlates with promoter methylation of the DNA repair enzyme O-6-methylguanine-DNA methyltransferase (MGMT). To improve treatment of GBMs, including t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Williford, Sarah E., Libby, Catherine J., Ayokanmbi, Adetokunbo, Otamias, Arphaxad, Gordillo, Juan J., Gordon, Emily R., Cooper, Sara J., Redmann, Matthew, Li, Yanjie, Griguer, Corinne, Zhang, Jianhua, Napierala, Marek, Ananthan, Subramaniam, Hjelmeland, Anita B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096095/
https://ncbi.nlm.nih.gov/pubmed/33945569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0250649
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