Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma

Cell surface expression levels of GPRC5D, an orphan G protein–coupled receptor, are significantly higher on multiple myeloma (MM) cells, compared with normal plasma cells or other immune cells, which renders it a promising target for immunotherapeutic strategies. The novel GPRC5D-targeting T-cell re...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Blood Adv
मुख्य लेखकों: Verkleij, Christie P. M., Broekmans, Marloes E. C., van Duin, Mark, Frerichs, Kristine A., Kuiper, Rowan, de Jonge, A. Vera, Kaiser, Martin, Morgan, Gareth, Axel, Amy, Boominathan, Rengasamy, Sendecki, Jocelyn, Wong, Amy, Verona, Raluca I., Sonneveld, Pieter, Zweegman, Sonja, Adams, Homer C., Mutis, Tuna, van de Donk, Niels W. C. J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Hematology 2021
विषय:
Lymphoid Neoplasia
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095149/
https://ncbi.nlm.nih.gov/pubmed/33890981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003805
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