Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma

Cell surface expression levels of GPRC5D, an orphan G protein–coupled receptor, are significantly higher on multiple myeloma (MM) cells, compared with normal plasma cells or other immune cells, which renders it a promising target for immunotherapeutic strategies. The novel GPRC5D-targeting T-cell re...

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Udgivet i:Blood Adv
Main Authors: Verkleij, Christie P. M., Broekmans, Marloes E. C., van Duin, Mark, Frerichs, Kristine A., Kuiper, Rowan, de Jonge, A. Vera, Kaiser, Martin, Morgan, Gareth, Axel, Amy, Boominathan, Rengasamy, Sendecki, Jocelyn, Wong, Amy, Verona, Raluca I., Sonneveld, Pieter, Zweegman, Sonja, Adams, Homer C., Mutis, Tuna, van de Donk, Niels W. C. J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2021
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095149/
https://ncbi.nlm.nih.gov/pubmed/33890981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003805
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