Inhibiting autophagy targets human leukemic stem cells and hypoxic AML blasts by disrupting mitochondrial homeostasis

Leukemia stem cells (LSCs) and therapy-resistant acute myeloid leukemia (AML) blasts contribute to the reinitiation of leukemia after remission, necessitating therapeutic interventions that target these populations. Autophagy is a prosurvival process that allows for cells to adapt to a variety of st...

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Pubblicato in:Blood Adv
Autori principali: Dykstra, Kaitlyn M., Fay, Hannah R. S., Massey, Ashish C., Yang, Neng, Johnson, Matthew, Portwood, Scott, Guzman, Monica L., Wang, Eunice S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2021
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095145/
https://ncbi.nlm.nih.gov/pubmed/33877295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002666
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