Discovery and characterization of small-molecule inhibitors of NLRP3 and NLRC4 inflammasomes

Inflammasomes are macromolecular complexes involved in the host response to external and endogenous danger signals. Inflammasome-mediated sterile inflammation plays a central role in several human conditions such as autoimmune diseases, type-2 diabetes, and neurodegenerative disorders, indicating in...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Sebastian-Valverde, Maria, Wu, Henry, Al Rahim, Md, Sanchez, Roberto, Kumar, Kunal, De Vita, Robert J., Pasinetti, Giulio Maria
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095128/
https://ncbi.nlm.nih.gov/pubmed/33781745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100597
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