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Discovery and characterization of small-molecule inhibitors of NLRP3 and NLRC4 inflammasomes
Inflammasomes are macromolecular complexes involved in the host response to external and endogenous danger signals. Inflammasome-mediated sterile inflammation plays a central role in several human conditions such as autoimmune diseases, type-2 diabetes, and neurodegenerative disorders, indicating in...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8095128/ https://ncbi.nlm.nih.gov/pubmed/33781745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100597 |
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