κ-Opioid receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats

Although opioids are potent analgesics, a consequence of chronic opioid use is hyperalgesia during withdrawal, which may contribute to opioid misuse. Dynorphin, the endogenous ligand of κ-opioid receptors (KORs), is upregulated in opioid-dependent rats and in animal models of chronic pain. However,...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Neurobiol Stress
Main Authors: Marchette, Renata C.N., Gregory-Flores, Adriana, Tunstall, Brendan J., Carlson, Erika R., Jackson, Shelley N., Sulima, Agnieszka, Rice, Kenner C., Koob, George F., Vendruscolo, Leandro F.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095052/
https://ncbi.nlm.nih.gov/pubmed/33997152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ynstr.2021.100325
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados