Interdomain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus responsible for chikungunya fever. Nonstructural protein 2 (nsP2), a multifunctional protein essential for viral replication, has an N-terminal helicase region (nsP2h), which has both nucleotide triphosphatase and RNA triphosphatase activities...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Law, Yee-Song, Wang, Sainan, Tan, Yaw Bia, Shih, Orion, Utt, Age, Goh, Wei Yang, Lian, Bing-Jun, Chen, Ming Wei, Jeng, U-Ser, Merits, Andres, Luo, Dahai
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094934/
https://ncbi.nlm.nih.gov/pubmed/33328310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01470-20
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