Presence of Tissue Transglutaminase in Granular Endoplasmic Reticulum is Characteristic of Melanized Neurons in Parkinson's Disease Brain

Parkinson's disease (PD) is characterized by the accumulation of α‐synuclein aggregates and degeneration of melanized neurons. The tissue transglutaminase (tTG) enzyme catalyzes molecular protein cross‐linking. In PD brain, tTG‐induced cross‐links have been identified in α‐synuclein monomers, o...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Brain Pathol
Autori principali: Wilhelmus, Micha M. M., Verhaar, Robin, Andringa, Gerda, Bol, John G. J. M., Cras, Patrick, Shan, Ling, Hoozemans, Jeroen J. M., Drukarch, Benjamin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2010
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094245/
https://ncbi.nlm.nih.gov/pubmed/20731657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2010.00429.x
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