Presence of Tissue Transglutaminase in Granular Endoplasmic Reticulum is Characteristic of Melanized Neurons in Parkinson's Disease Brain

Parkinson's disease (PD) is characterized by the accumulation of α‐synuclein aggregates and degeneration of melanized neurons. The tissue transglutaminase (tTG) enzyme catalyzes molecular protein cross‐linking. In PD brain, tTG‐induced cross‐links have been identified in α‐synuclein monomers, o...

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Detalhes bibliográficos
Publicado no:Brain Pathol
Main Authors: Wilhelmus, Micha M. M., Verhaar, Robin, Andringa, Gerda, Bol, John G. J. M., Cras, Patrick, Shan, Ling, Hoozemans, Jeroen J. M., Drukarch, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094245/
https://ncbi.nlm.nih.gov/pubmed/20731657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2010.00429.x
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