The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia

Venetoclax is a promising agent in the treatment of acute myeloid leukemia (AML), though its antileukemic activity is limited to combination therapies. Mcl-1 downregulation, Bim upregulation, and DNA damage have been identified as potential ways to enhance venetoclax activity. In this study, we comb...

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Bibliographic Details
Published in:Haematologica
Main Authors: Li, Xinyu, Su, Yongwei, Hege, Katie, Madlambayan, Gerard, Edwards, Holly, Knight, Tristan, Polin, Lisa, Kushner, Juiwanna, Dzinic, Sijana H., White, Kathryn, Yang, Jay, Miller, Regan, Wang, Guan, Zhao, Lijing, Wang, Yue, Lin, Hai, Taub, Jeffrey W., Ge, Yubin
Format: Artigo
Language:Inglês
Published: Fondazione Ferrata Storti 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094102/
https://ncbi.nlm.nih.gov/pubmed/32165486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.233445
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