Antileukemic activity and mechanism of action of the novel PI3K and histone deacetylase dual inhibitor CUDC-907 in acute myeloid leukemia

Induction therapy for patients with acute myeloid leukemia (AML) has remained largely unchanged for over 40 years, while overall survival rates remain unacceptably low, highlighting the need for new therapies. The PI3K/Akt pathway is constitutively active in the majority of patients with AML. Given...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Haematologica
मुख्य लेखकों: Li, Xinyu, Su, Yongwei, Madlambayan, Gerard, Edwards, Holly, Polin, Lisa, Kushner, Juiwanna, Dzinic, Sijana H., White, Kathryn, Ma, Jun, Knight, Tristan, Wang, Guan, Wang, Yue, Yang, Jay, Taub, Jeffrey W., Lin, Hai, Ge, Yubin
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Ferrata Storti Foundation 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821619/
https://ncbi.nlm.nih.gov/pubmed/30819918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.201343
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