Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation

Targeting oxidative phosphorylation (OXPHOS) is a promising strategy to improve treatment outcomes of acute myeloid leukemia (AML) patients. IACS-010759 is a mitochondrial complex I inhibitor that has demonstrated preclinical antileukemic activity and is being tested in Phase I clinical trials. Howe...

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I publikationen:Cancers (Basel)
Huvudupphovsmän: Liu, Fangbing, Kalpage, Hasini A., Wang, Deying, Edwards, Holly, Hüttemann, Maik, Ma, Jun, Su, Yongwei, Carter, Jenna, Li, Xinyu, Polin, Lisa, Kushner, Juiwanna, Dzinic, Sijana H., White, Kathryn, Wang, Guan, Taub, Jeffrey W., Ge, Yubin
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7564145/
https://ncbi.nlm.nih.gov/pubmed/32847115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12092400
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