Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation

Targeting oxidative phosphorylation (OXPHOS) is a promising strategy to improve treatment outcomes of acute myeloid leukemia (AML) patients. IACS-010759 is a mitochondrial complex I inhibitor that has demonstrated preclinical antileukemic activity and is being tested in Phase I clinical trials. Howe...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Liu, Fangbing, Kalpage, Hasini A., Wang, Deying, Edwards, Holly, Hüttemann, Maik, Ma, Jun, Su, Yongwei, Carter, Jenna, Li, Xinyu, Polin, Lisa, Kushner, Juiwanna, Dzinic, Sijana H., White, Kathryn, Wang, Guan, Taub, Jeffrey W., Ge, Yubin
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7564145/
https://ncbi.nlm.nih.gov/pubmed/32847115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12092400
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