Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation

Targeting oxidative phosphorylation (OXPHOS) is a promising strategy to improve treatment outcomes of acute myeloid leukemia (AML) patients. IACS-010759 is a mitochondrial complex I inhibitor that has demonstrated preclinical antileukemic activity and is being tested in Phase I clinical trials. Howe...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Cancers (Basel)
Glavni autori: Liu, Fangbing, Kalpage, Hasini A., Wang, Deying, Edwards, Holly, Hüttemann, Maik, Ma, Jun, Su, Yongwei, Carter, Jenna, Li, Xinyu, Polin, Lisa, Kushner, Juiwanna, Dzinic, Sijana H., White, Kathryn, Wang, Guan, Taub, Jeffrey W., Ge, Yubin
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7564145/
https://ncbi.nlm.nih.gov/pubmed/32847115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12092400
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items