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Individualized dosing guidelines for PEGasparaginase and factors influencing the clearance: a population pharmacokinetic model
Considerable inter- and intra-patient variability exist in serum activity levels of PEGasparaginase, essential for pediatric acute lymphoblastic leukemia (ALL) treatment. A population pharmacokinetic (popPK) model was developed, identifying patient characteristics that explain these variabilities. P...
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| Veröffentlicht in: | Haematologica |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Fondazione Ferrata Storti
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8094082/ https://ncbi.nlm.nih.gov/pubmed/32327497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.242289 |
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