Population pharmacokinetics of intravenous Erwinia asparaginase in pediatric acute lymphoblastic leukemia patients

Erwinia asparaginase is an important component in the treatment of pediatric acute lymphoblastic leukemia. A large variability in serum concentrations has been observed after intravenous Erwinia asparaginase. Currently, Dutch Childhood Oncology Group protocols dose alterations are based on trough co...

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Udgivet i:Haematologica
Main Authors: Sassen, Sebastiaan D.T., Mathôt, Ron A.A., Pieters, Rob, Kloos, Robin Q.H., de Haas, Valérie, Kaspers, Gertjan J.L., van den Bos, Cor, Tissing, Wim J.E., te Loo, Maroeska, Bierings, Marc B., Kollen, Wouter J.W., Zwaan, Christian M., van der Sluis, Inge M.
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5394946/
https://ncbi.nlm.nih.gov/pubmed/28250007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.149195
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