MDM2 inhibitor APG-115 exerts potent antitumor activity and synergizes with standard-of-care agents in preclinical acute myeloid leukemia models

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous clonal disease associated with unmet medical needs. Paralleling the pathology of other cancers, AML tumorigenesis and propagation can be ascribed to dysregulated cellular processes, including apoptosis. This function and othe...

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Publicat a:Cell Death Discov
Autors principals: Fang, Douglas D., Tang, Qiuqiong, Kong, Yanhui, Rong, Tao, Wang, Qixin, Li, Na, Fang, Xu, Gu, Jiaxing, Xiong, Dengkun, Yin, Yan, Deng, Jing, Yang, Dajun, Zhai, Yifan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093284/
https://ncbi.nlm.nih.gov/pubmed/33941774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-021-00465-5
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