Missense Mutations in the CrrB Protein Mediate Odilorhabdin Derivative Resistance in Klebsiella pneumoniae

NOSO-502 is a preclinical antibiotic candidate of the odilorhabdin class. This compound exhibits activity against Enterobacteriaceae pathogens, including carbapenemase-producing bacteria and most of the colistin (CST)-resistant strains. Among a collection of CST-resistant Klebsiella pneumoniae strai...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Pantel, Lucile, Juarez, Paulo, Serri, Marine, Boucinha, Lilia, Lessoud, Emilie, Lanois, Anne, Givaudan, Alain, Racine, Emilie, Gualtieri, Maxime
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092918/
https://ncbi.nlm.nih.gov/pubmed/33685902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00139-21
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