Nybomycin Inhibits both Fluoroquinolone-Sensitive and Fluoroquinolone-Resistant Escherichia coli DNA Gyrase

Bacterial type II topoisomerases, DNA gyrase and topoisomerase IV, are targets of many antibiotics, including fluoroquinolones (FQs). Unfortunately, a number of bacterial species easily acquire resistance to FQs by mutations in either DNA gyrase or topoisomerase IV genes. The emergence of resistant...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Shiriaev, Dmitrii I., Sofronova, Alina A., Berdnikovich, Ekaterina A., Lukianov, Dmitrii A., Komarova, Ekaterina S., Marina, Valeriya I., Zakalyukina, Yuliya V., Biryukov, Mikhail V., Maviza, Tinashe P., Ivanenkov, Yan A., Sergiev, Petr V., Osterman, Ilya A., Dontsova, Olga A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2021
Soggetti:
Chemistry; Biosynthesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092900/
https://ncbi.nlm.nih.gov/pubmed/33593838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00777-20
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