GS-9822, a Preclinical LEDGIN Candidate, Displays a Block-and-Lock Phenotype in Cell Culture

The ability of HIV to integrate into the host genome and establish latent reservoirs is the main hurdle preventing an HIV cure. LEDGINs are small-molecule integrase inhibitors that target the binding pocket of LEDGF/p75, a cellular cofactor that substantially contributes to HIV integration site sele...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Bruggemans, Anne, Vansant, Gerlinde, Balakrishnan, Mini, Mitchell, Michael L., Cai, Ruby, Christ, Frauke, Debyser, Zeger
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2021
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092873/
https://ncbi.nlm.nih.gov/pubmed/33619061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02328-20
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