Regulation of VP30-Dependent Transcription by RNA Sequence and Structure in the Genomic Ebola Virus Promoter

Viral transcription and replication of Ebola virus (EBOV) are balanced by transcription factor VP30, an RNA-binding protein. An RNA hairpin at the transcription start site (TSS) of the first gene (NP hairpin) in the 3′-leader promoter is thought to mediate the VP30 dependency of transcription. Here,...

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Udgivet i:J Virol
Main Authors: Bach, Simone, Demper, Jana-Christin, Grünweller, Arnold, Becker, Stephan, Biedenkopf, Nadine, Hartmann, Roland K.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
Fag:
Genome Replication and Regulation of Viral Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092829/
https://ncbi.nlm.nih.gov/pubmed/33268520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02215-20
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