Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains

Insulin and insulin-like growth factor 1 (IGF-1) receptors share many downstream signaling pathways but have unique biological effects. To define the molecular signals contributing to these distinct activities, we performed global phosphoproteomics on cells expressing either insulin receptor (IR), I...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nagao, Hirofumi, Cai, Weikang, Wewer Albrechtsen, Nicolai J., Steger, Martin, Batista, Thiago M., Pan, Hui, Dreyfuss, Jonathan M., Mann, Matthias, Kahn, C. Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092608/
https://ncbi.nlm.nih.gov/pubmed/33879610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019474118
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