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Ion mobility–mass spectrometry reveals the role of peripheral myelin protein dimers in peripheral neuropathy
Peripheral myelin protein (PMP22) is an integral membrane protein that traffics inefficiently even in wild-type (WT) form, with only 20% of the WT protein reaching its final plasma membrane destination in myelinating Schwann cells. Misfolding of PMP22 has been identified as a key factor in multiple...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8092585/ https://ncbi.nlm.nih.gov/pubmed/33893233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015331118 |
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