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Predicting the Disposition of the Antimalarial Drug Artesunate and Its Active Metabolite Dihydroartemisinin Using Physiologically Based Pharmacokinetic Modeling

Artemisinin-based combination therapies (ACTs) have proven to be effective in helping to combat the global malaria epidemic. To optimally apply these drugs, information about their tissue-specific disposition is required, and one approach to predict these pharmacokinetic characteristics is physiolog...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Arey, Ryan, Reisfeld, Brad
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092529/
https://ncbi.nlm.nih.gov/pubmed/33361307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02280-20
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