Metabolic and physiologic imaging biomarkers of the tumor microenvironment predict treatment outcome with radiation or a hypoxia-activated prodrug in mice.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxic niches that lead to treatment resistance. Therefore, studies of tumor oxygenation and metabolic profiling should contribute to improved treatment strategies. Here we define two imaging biomarkers that predict differences in tumor re...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Matsumoto, Shingo, Kishimoto, Shun, Saito, Keita, Takakusagi, Yoichi, Munasinghe, Jeeva P., Devasahayam, Nallathamby, Hart, Charles, Gillies, Robert J., Mitchell, James B., Krishna, Murali C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092078/
https://ncbi.nlm.nih.gov/pubmed/29792309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0491
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