Discovery of Antibacterials That Inhibit Bacterial RNA Polymerase Interactions with Sigma Factors

Formation of a bacterial RNA polymerase (RNAP) holoenzyme by a catalytic core RNAP and a sigma (σ) initiation factor is essential for bacterial viability. As the primary binding site for the housekeeping σ factors, the RNAP clamp helix domain represents an attractive target for novel antimicrobial a...

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Gepubliceerd in:J Med Chem
Hoofdauteurs: Ye, Jiqing, Chu, Adrian Jun, Harper, Rachel, Chan, Shu Ting, Shek, Tsun Lam, Zhang, Yufeng, Ip, Margaret, Sambir, Mariya, Artsimovitch, Irina, Zuo, Zhong, Yang, Xiao, Ma, Cong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091929/
https://ncbi.nlm.nih.gov/pubmed/32633513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00520
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