Benzyl and Benzoyl Benzoic Acid Inhibitors of Bacterial RNA Polymerase-Sigma Factor Interaction

Transcription is an essential biological process in bacteria requiring a core enzyme, RNA polymerase (RNAP). Bacterial RNAP is catalytically active but requires sigma (σ) factors for transcription of natural DNA templates. σ factor binds to RNAP to form a holoenzyme which specifically recognizes a p...

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Publicado en:Eur J Med Chem
Main Authors: Ye, Jiqing, Chu, Adrian Jun, Lin, Lin, Chan, Shu Ting, Harper, Rachel, Xiao, Min, Artsimovitch, Irina, Zuo, Zhong, Ma, Cong, Yang, Xiao
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680358/
https://ncbi.nlm.nih.gov/pubmed/32920341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112671
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