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In silico discovery of small molecules that inhibit RfaH recruitment to RNA polymerase
RfaH is required for virulence in several Gram-negative pathogens including Escherichia coli and Klebsiella pneumoniae. Through direct interactions with RNA polymerase (RNAP) and ribosome, RfaH activates the expression of capsule, cell wall and pilus biosynthesis operons by reducing transcription te...
Tallennettuna:
| Julkaisussa: | Mol Microbiol |
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| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6595482/ https://ncbi.nlm.nih.gov/pubmed/30069925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.14093 |
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